Tetrahedron

Thiazo rifamycins—I: Structure and synthesis of rifamycins p, q and verde, novel metabolites from mutants of nocardia mediterranea

R Cricchio, P Antonini, GC Lancini, G Tamborini…

Index: Cricchio, R.; Antonini, P.; Lancini, G. C.; Tamborini, G.; White, R. J.; Martinelli, E. Tetrahedron, 1980 , vol. 36, p. 1415 - 1421

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Citation Number: 17

Abstract

Structures 1, 2 and 3 have been assigned to rifamycins P, Q and Verde, novel metabolites isolated from a mutant strain of Nocardia mediterranea both on the basis of spectroscopic evidence (UV, IR, MS, 1H and 13C NMR) in comparison with the model compounds rifamycin S (4), rifampicin (5) and 4-dimethylamino-4-deoxy-rifamycin SV (6), and of an unambiguous synthesis from rifamycin S (4).