2-(1-Adamantyl)-4-(thio) chromenone-6-carboxylic acids: potent reversible inhibitors of human steroid sulfatase

A Horvath, P Nussbaumer, B Wolff…

Index: Yavrouian, Andre H.; Sanchez, Robert A.; Pollard, John K.; Metzner, E. Kurt Synthesis, 1981 , # 10 p. 791 - 793

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Citation Number: 34

Abstract

... form, toluene, 2 h, reflux, 67%; (d) CH 3 COOK, CH 3 COOH, 120°C, 12 h, 56%; (e) CH 3 ... OH) 2 , PPh 3 , DMF, 100 °C, 1 h, 36%; (c) 20% HCl, dioxane, 120 °C, 16 h, 50 ... sulfate (4-MUS) as a synthetic substrate for a convenient colorimetric assay to determine IC 50 or K i values of ...