The Journal of Organic Chemistry

Addition of alkyl and aryl isocyanides to benzyne

JH Rigby, S Laurent

Index: Rigby, James H.; Laurent, Stephane Journal of Organic Chemistry, 1998 , vol. 63, # 19 p. 6742 - 6744

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Citation Number: 31

Abstract

Isocyanates are known to react with a wide range of nucleophilic partners to effect a net installation of a carbamoyl moiety. 1 In contrast to the electrophilic nature of the isocyanate function, the well-known nucleophilicity of isocyanides suggests that this group could serve as an umpoled version of the former species when reacted under certain circumstances with appropriate electrophiles (Figure 1).