Preparation of macrocyclic lactones by ring closure of cesium carboxylates

WH Kruizinga, RM Kellogg

Index: Kruizinga, Wim H.; Kellogg, Richard M. Journal of the American Chemical Society, 1981 , vol. 103, # 17 p. 5183 - 5189

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Citation Number: 132

Abstract

Results An approach to macrocyclic lactones by ring closure of cesium carboxylates requires that the substrate be a long-chain acid with a good leaving group at the site at which ring closure must occur (eq 3). Equation 3 contains, of course, the basic chemical tenets