Synthesis, SAR, and antitumor properties of diamino-C, N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-β

B Gong, F Hong, C Kohm, S Jenkins, J Tulinsky…

Index: Gong, Baoqing; Hong, Feng; Kohm, Cory; Jenkins, Scott; Tulinsky, John; Bhatt, Rama; De Vries, Peter; Singer, Jack W.; Klein, Peter Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2303 - 2308

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Citation Number: 22

Abstract

2, 4-Diamino-N4, 6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-β (LPAAT-β). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in vivo tumor model was investigated.