−(±)-5-Me-8-OH-DPAT 4 was synthesized by a new synthetic pathway recently described by us. The (+)-and (−)-enantiomers 4 were prepared from the primary amine 8 by crystallisation of the (+)-and (−)-mandelic acid salts. The enantiomers reacted with propyl iodide and were demethylated by 48% HBr to the (+)-and (−)-4 compounds. These compounds had good affinity for 5-HT1A receptors (Ki= 32.9±0.8 and 45.6±2 nM, respectively) but lacked ...
