e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Reactions with Heterocyclic Amidines, X: Synthesis of Some New Azolylthiourea Derivatives

SM Fahmy, MKA Ibraheim, K Abouhadid…

Index: Fahmy; Ibraheim; Abouhadid; et al. Archiv der Pharmazie, 1982 , vol. 315, # 9 p. 791 - 797

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Citation Number: 3

Abstract

Abstract A variety of azolylthiourea derivatives were prepared by the reaction of heterocyclic amidines with ethoxycarbonyl isothiocyanate or benzoyl isothiocyanate. The synthesized azolylthioureas were converted into polycyclic derivatives by treatment with alkali and hydrazines.

5-amino-1,3-diphenylpyrazole Structure

5-amino-1,3-dip...

benzoylthiocarbimide Structure

benzoylthiocarbimide

~96%

N-[(2,5-diphenylpyrazol-3-yl)carbamothioyl]benzamide Structure

N-[(2,5-dipheny...

Structure

~82%

(5-amino-1-phenyl-1,2,4-triazol-3-yl)thiourea Structure

(5-amino-1-phen...

N-((5-amino-1-phenyl-1H-1,2,4-triazol-3-yl)carbamothioyl)benzamide Structure

N-((5-amino-1-p...

~77%

(5-amino-1-phenyl-1,2,4-triazol-3-yl)thiourea Structure

(5-amino-1-phen...

1H-1,2,4-Triazole-3,5-diamine,1-phenyl- Structure

1H-1,2,4-Triazo...

~%

(5-amino-1-phenyl-1,2,4-triazol-3-yl)thiourea Structure

(5-amino-1-phen...

5-amino-1,3-diphenylpyrazole Structure

5-amino-1,3-dip...

~%

1-anilino-2-(2,5-diphenylpyrazol-3-yl)guanidine Structure

1-anilino-2-(2,...

Phenylhydrazine Structure

Phenylhydrazine

N-[(2,5-diphenylpyrazol-3-yl)carbamothioyl]benzamide Structure

N-[(2,5-dipheny...

~40%

1-anilino-2-(2,5-diphenylpyrazol-3-yl)guanidine Structure

1-anilino-2-(2,...

N-[(2,5-diphenylpyrazol-3-yl)carbamothioyl]benzamide Structure

N-[(2,5-dipheny...

~61%

(2,5-diphenylpyrazol-3-yl)thiourea Structure

(2,5-diphenylpy...

5-amino-1,3-diphenylpyrazole Structure

5-amino-1,3-dip...

~%

(2,5-diphenylpyrazol-3-yl)thiourea Structure

(2,5-diphenylpy...

Ethanoic anhydride Structure

Ethanoic anhydride

1-Ethoxycarbonyl-3-(5-ethoxycarbonyl-4-methylthiazol-2-yl)thiourea Structure

1-Ethoxycarbony...

~70%

5-Thiazolecarboxylicacid, 2-(acetylamino)-4-methyl-, ethyl ester Structure

5-Thiazolecarbo...

Ethanoic anhydride Structure

Ethanoic anhydride

1-Benzoyl-3-(5-ethoxycarbonyl-4-methylthiazol-2-yl)thiourea Structure

1-Benzoyl-3-(5-...

~68%

5-Thiazolecarboxylicacid, 2-(acetylamino)-4-methyl-, ethyl ester Structure

5-Thiazolecarbo...

Ethyl 2-amino-4-methylthiazole-5-carboxylate Structure

Ethyl 2-amino-4...

~%

5-Thiazolecarboxylicacid, 2-(acetylamino)-4-methyl-, ethyl ester Structure

5-Thiazolecarbo...

2-Aminobenzimidazole Structure

2-Aminobenzimidazole

~%

N-(1H-BENZO[D]IMIDAZOL-2-YL)ACETAMIDE Structure

N-(1H-BENZO[D]I...

Ethanoic anhydride Structure

Ethanoic anhydride

N-(1H-benzimidazol-2-ylcarbamothioyl)benzamide Structure

N-(1H-benzimida...

~%

N-(1H-BENZO[D]IMIDAZOL-2-YL)ACETAMIDE Structure

N-(1H-BENZO[D]I...