Synthesis and central nervous system properties of 2-[(alkoxycarbonyl) amino]-4 (5)-phenyl-2-imidazolines

K Weinhardt, CC Beard, C Dvorak, M Marx…

Index: Weinhardt; Beard; Dvorak; Marx; Patterson; Roszkowski; Schuler; Unger; Wagner; Wallach Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 616 - 627

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Citation Number: 15

Abstract

A series of 2-[(alkoxycarbonyl) amino]-4 (5)-phenyl-2-imidazolines was prepared and evaluated for central nervous system (CNS) effects (antidepressant, anticonvulsant, muscle relaxant, and depressant) in animal models. Some separation of those CNS activities was achieved through substitutions on the phenyl and imidazoline moieties. Halo-substituted phenyl compounds were among the most potent antidepressants in this series, while ...