Cytotoxicity of lapachol, β-lapachone and related synthetic 1, 4-naphthoquinones against oesophageal cancer cells

…, N Shunmoogam-Gounden, O Osoniyi…

Index: Sunassee, Suthananda N.; Veale, Clinton G.L.; Shunmoogam-Gounden, Nelusha; Osoniyi, Omalaja; Hendricks, Denver T.; Caira, Mino R.; De La Mare, Jo-Anne; Edkins, Adrienne L.; Pinto, Antonio V.; Da Silva Junior, Eufranio N.; Davies-Coleman, Michael T. European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 98 - 110

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Citation Number: 22

Abstract

Naphthoquinones have been found to have a wide range of biological activities, including cytotoxicity to cancer cells. The secondary metabolites lapachol, α-and β-lapachone and a series of 25 related synthetic 1, 4-naphthoquinones were screened against the oesophageal cancer cell line (WHCO1). Most of the compounds exhibited enhanced cytotoxicity (IC50 1.6– 11.7 μM) compared to the current drug of choice cisplatin (IC50= 16.5 μM). This study also ...