Tetrahedron: Asymmetry

Asymmetric reduction of nitroalkenes with baker's yeast

Y Kawai, Y Inaba, N Tokitoh

Index: Kawai, Yasushi; Inaba, Yoshikazu; Tokitoh, Norihiro Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 309 - 318

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Citation Number: 58

Abstract

Various α, β-disubstituted and trisubstituted nitroalkenes were chemoselectively reduced with baker's yeast to the corresponding nitroalkanes. Stereoselectivities of the reduction of α, β-disubstituted nitroalkenes were modest to low, and ees up to 52% were obtained. Trisubstituted nitroalkenes could be reduced to the corresponding nitroalkanes with excellent enantioselectivities, moderate diastereoselectivities and in good yield.