European Journal of Organic Chemistry

Discovery of a robust and efficient homogeneous silver (I) catalyst for the cycloaddition of azides onto terminal alkynes

J McNulty, K Keskar

Index: McNulty, James; Keskar, Kunal European Journal of Organic Chemistry, 2012 , # 28 p. 5462 - 5470

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Citation Number: 29

Abstract

Abstract A highly efficient, chemically stable, and well-defined homogeneous silver (I) catalyst is reported for the cycloaddition of azides onto terminal alkynes (Ag-AAC reaction). The Ag-AAC reaction occurs at room temperature or with heating to deliver exclusively the corresponding 1, 4-triazole. A pronounced ligand effect was discovered through systematic modification to the ligand structure resulting in the discovery of a chemically stable active ...