In summary, the methyl-and bromo-substituted compounds behave similarly, indicating that steric factors are more significant to the activity than electronic forces. The inactivity of the 2, 3-disubstituted derivatives 3b and 3c may be explained by the steric interaction between the 3-substituent and the 2-methoxyl which may force the methoxyl group to interfere with the interaction of the $-hydroxyl group and the receptor. It is of interest that some 2- ...
![bis[3-[2-(diethylamino)ethoxy]phenyl]methanone Structure](https://image.chemsrc.com/caspic/381/67588-09-4.png)