Chemical Communications

Kulinkovich-type reactions of thioamides: similar to those of carboxylic amides?

E Augustowska, A Boiron, J Deffit, Y Six

Index: Augustowska, Ewelina; Boiron, Antoine; Deffit, Jerome; Six, Yvan Chemical Communications, 2012 , vol. 48, # 41 p. 5031 - 5033

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Citation Number: 4

Abstract

Since the original report by the group of Kulinkovich in 1989, 1 the transformations mediated by excess amounts of Grignard reagents in the presence of alkoxytitanium(IV) species of the type XTi(OiPr) 3 (X = Cl, OiPr) have emerged as a family of powerful reactions with remarkably broad scope. 2 In particular, the Kulinkovich–de Meijere cyclopropanation of carboxylic amides can now be considered as the method of choice for the synthesis of tertiary ...