e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
An one-pot approach to the synthesis of triazolobenzothiadiazepine 1, 1-dioxide derivatives by basic alumina-supported azide–alkyne [3+ 2] cycloaddition
An efficient one-pot strategy for the synthesis of triazolobenzothiadiazepine 1, 1-dioxide derivatives has been developed by the reaction of 2-azido-N-substituted benzenesulfonamides and propargyl bromide in basic alumina under microwave condition via [3+ 2] azide–alkyne cycloaddition reaction. This protocol has synthetic advantages in terms of low environmental impact and short reaction time.
