Synthesis of genotoxic heterocyclic amines Trp-P-1 and Trp-P-2

S Hibino, E Sugino, T Kuwada, N Ogura…

Index: Hibino, Satoshi; Sugino, Eiichi; Kuwada, Takeshi; Ogura, Naoki; Sato, Kohichi; Choshi, Tominari Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5917 - 5921

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Citation Number: 44

Abstract

2b: R= R= H ring systems, by the thermal electrocyclic reaction of monoazahexa-1, 3, 5- triene systems including one double bond of the aromatic or heteroar~ matic.~ In 1984, we reported a new synthesis of pyrido [4, 3-b] indoles by the electrocyclic reaction of the l- azahexa-1, 3, 5-triene system involving the indole [b] bond.% We now describe here the synthesis of Trp-P-1 (la) and Trp-P-2 (lb) by an application of this methodology to the y- ...