The DNA strand-breaking activity of some dihydropyrazine derivatives, 2, 3-dihydro-5, 6- dimethylpyrazine (3), 2, 3-dihydro-2, 5, 6-trimethylpyrazine (4), 2, 3-dihydro-2, 2, 5, 6- tetramethylpyrazine (5), trans-2, 3-dimethyl-5, 6, 7, 8, 9, 10-hexahydroquinoxaline (6), its cis- compound (7) and the mixture of 6 and 7 (8) was tested by agarose gel electrophoresis using plasmide pBR322 ccc-DNA as a substrate. The order of DNA strand-breaking ...
