Tetrahedron Letters

A general method for regioselective Heck arylation of electron-rich N-acyl-N-vinylamine with aryl halides

Z Liu, D Xu, W Tang, L Xu, J Mo, J Xiao

Index: Liu, Zhihua; Xu, Dan; Tang, Weijun; Xu, Lijin; Mo, Jun; Xiao, Jianliang Tetrahedron Letters, 2008 , vol. 49, # 17 p. 2756 - 2760

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Citation Number: 24

Abstract

A highly efficient protocol for the Pd-catalyzed regioselective Heck arylation of the electron- rich olefin N-acyl-N-vinylamine with aryl halides has been developed. In the presence of hydrogen-bond donor [H2NiPr2][BF4] as an additive, this proceeds smoothly in isopropanol to afford exclusively the branched products in high yields.