Synthesis of a new class of 2, 3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists

…, M Gil Quintero, L Maiocchi, R Micheletti…

Index: Turconi, Marco; Nicola, Massimo; Quintero, Myrna Gil; Maiocchi, Luciano; Micheletti, Rosella; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2101 - 2108

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Citation Number: 75

Abstract

R2 compd Ra R1 methodb% yield mp, OC crystn solvent formula 7a AA HHE 47 191-192 CHSCN C16H19N303 7b BB HHE 68 255-256 i-PrOH C16H1, N3O3* HCl 7c CC HHE 33 259-261 EtOH/Et, O C16H17N303* HCl 7d DD HHE 44 219-220 EtOH CllH17N30, yHCl 7e EE HHE 84 250-252 EtOH/EbO C16H21N303. HC1 7f FF HHE 64 258-260 EtOH C17HziN303* HCl