Synlett

One-Pot, Three-Component Synthesis of 4-Aryl-5, 6-dihydropyran via Prins-Friedel-Crafts Reaction

UC Reddy, AK Saikia

Index: Reddy, Udagandla C.; Saikia, Anil K. Synlett, 2010 , # 7 p. 1027 - 1032

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Citation Number: 10

Abstract

The scope of the reaction was examined by considering a range of aldehydes as shown in Table [¹] . It was observed that the reaction holds good for simple aromatic aldehydes and aldehydes having electron-withdrawing groups on the aromatic ring. Aromatic aldehydes having electron-donating groups such as anisaldehyde failed to give products. This can be attributed to the stability of the benzylic carbocation due to the presence of methoxy group on the ...