Anti human immunodeficiency virus type 1 (HIV-1) agents 4. Discovery of 5, 5'-(p-phenylenebisazo)-8-hydroxyquinoline sulfonates as new HIV-1 inhibitors in vitro

XW Zeng, N Huang, H Xu, WB Yang, LM Yang…

Index: Zeng, Xi-Wen; Huang, Ning; Xu, Hui; Yang, Wen-Bin; Yang, Liu-Meng; Qu, Huan; Zheng, Yong-Tang Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 7 p. 976 - 979

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Citation Number: 6

Abstract

To search for compounds with superior anti-human immunodeficiency virus type 1 (HIV-1) activity, ten 5, 5′-(p-phenylenebisazo)-8-hydroxyquinoline sulfonates (4a—j) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Some compounds demonstrated anti-HIV-1 activity, especially 5, 5′-(p-phenylenebisazo)-8- hydroxyquinoline p-ethylbenzenesulfonate (4g) and 5, 5′-(p-phenylenebisazo)-8- ...