Structure–activity relationship in the 3-iodo-4-phenoxypyridinone (IOPY) series: The nature of the C-3 substituent on anti-HIV activity

…, J Guillemont, E Pasquier, D Mabire, K Andries…

Index: Benjahad, Abdellah; Oumouch, Said; Guillemont, Jerome; Pasquier, Elisabeth; Mabire, Dominique; Andries, Koen; Nguyen, Chi Hung; Grierson, David S. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 712 - 716

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Citation Number: 17

Abstract

As part of a systematic SAR study on the 3-iodo-4-phenoxypyridinone 3 (IOPY) type non- nucleoside reverse transcriptase inhibitors, the analogues 4a–4z bearing different C-3 substituents were synthesized and evaluated for their anti-HIV activity against wild-type ...