Synthesis and antimalarial activity of new 1, 12-bis (N, N′-acetamidinyl) dodecane derivatives

M Ouattara, S Wein, M Calas, YV Hoang, H Vial…

Index: Ouattara, Mahama; Wein, Sharon; Calas, Michele; Hoang, Yen Vo; Vial, Henri; Escale, Roger Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 593 - 596

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Citation Number: 19

Abstract

Amidoxime and O-substituted derivatives of the bis-alkylamidine 1, 12-bis (N, N′- acetamidinyl) dodecane were synthesized and evaluated as in vitro and in vivo antimalarial prodrugs. The bis-O-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives show relatively potent antimalarial activity after oral administration.