Synthesis of β-CF 3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization

…, X Pannecoucke, JL Renaud, D Cahard

Index: Bizet, Vincent; Pannecoucke, Xavier; Renaud, Jean-Luc; Cahard, Dominique Journal of Fluorine Chemistry, 2013 , vol. 152, p. 56 - 61

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Citation Number: 11

Abstract

This work describes the optimization process for the synthesis of β-trifluoromethylated ketones from trifluoromethylated allylic alcohols. This transformation proceeds through a ruthenium catalyzed isomerization under mild conditions with high atom economy. The effect of the CF3 group was analyzed and it provides fundamental insights into the isomerization reaction.