Silver (I) fluoride-mediated Pd-catalyzed C− H direct arylation/heteroarylation of 3- bromoisothiazole-4-carbonitrile (1a) gives twenty-four 5-aryl/heteroaryl-3-bromoisothiazole- 4-carbonitriles. The reaction was partially optimized with respect to catalyst, ligand, and base. During this study 3, 3′-dibromo-5, 5′-biisothiazole-4, 4′-dicarbonitrile (3a) was isolated as a byproduct and subsequently prepared via the silver-mediated Pd-catalyzed ...
