Steroids

Synthesis of deuterated isotopomers of 7α-and (25R, S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile …

P Ciuffreda, S Casati, L Alessandrini, G Terraneo…

Index: Ciuffreda, Pierangela; Casati, Silvana; Alessandrini, Laura; Terraneo, Giancarlo; Santaniello, Enzo Steroids, 2003 , vol. 68, # 9 p. 733 - 738

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Citation Number: 7

Abstract

Deuterated isotopomers of 7α-and (25R, S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids formation from cholesterol, were prepared from [2, 2, 3, 4, 4, 6-2H 6]-cholesterol and (20S)-[7, 7, 21, 21-2H 4]-3β-(tert- butyldimethylsilyl) oxy-20-methylpregna-5-en-21-ol, respectively.