e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Spirocyclopropane compounds. I. Synthesis and reactivity of spiro (cyclopropane-1, 2'-(2H) indol)-3'(1'H)-ones.

川田満，川野泰彦，杉原弘貞，武居三郎…

Index: Kawada; Kawano; Sugihara; et al. Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 7 p. 1900 - 1911

Full Text: HTML

Citation Number: 11

Abstract

... Pharm. Bu11. SmmSS 7)1900–1911(1981) Spirocyclopropane Compounds. I. Synthesis and Reactivity of Spiro[cyclopropane-1,2'-[2Hindol]-3'(1“H)-ones MiTsURU KAwADA,* YAsUHIKO KAwANO, HIRosADA SUGIHARA, SABURo TAKE, and IsUKE ...

Anthranilic acid Structure

Anthranilic acid

~%

Spiro[cyclopropane-1,2'-[2h]indol]-3'(1'H)-one Structure

Spiro[cycloprop...

1'-formyl-4,5-dihydrospiro[furan-3(2H),2'-[2H]indole]-2,3'(1'H)-dione Structure

1'-formyl-4,5-d...

~87%

3'-oxospiro[cyclopropane-1,2'-indole]-1'-carbaldehyde Structure

3'-oxospiro[cyc...

Anthranilic acid Structure

Anthranilic acid

~%

3'-oxospiro[cyclopropane-1,2'-indole]-1'-carbaldehyde Structure

3'-oxospiro[cyc...

benzyl 5'-t-butoxycarbonyl-3,4'-diethyl-4,3'-dimethyl-2,2'-dipyrrylmethane-5-carboxylate Structure

benzyl 5'-t-but...

~%

3'-oxospiro[cyclopropane-1,2'-indole]-1'-carbaldehyde Structure

3'-oxospiro[cyc...

4,5-dihydro-1'-methyl-1'H-spiro[furan-3(3H),2'-indoline]-2,3'-dione Structure

4,5-dihydro-1'-...

~90%

1'-methylspiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-methylspiro[...

N-Methylanthranilic acid Structure

N-Methylanthran...

~%

1'-methylspiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-methylspiro[...

2-[methyl-(2-oxooxolan-3-yl)amino]benzoic acid Structure

2-[methyl-(2-ox...

~%

1'-methylspiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-methylspiro[...

1'-acetyl-4,5-dihydro-5'-methoxy-1'H-spiro[furan-3(3H),2'-indoline]-2,3'-dione Structure

1'-acetyl-4,5-d...

~86%

1'-acetyl-5'-methoxyspiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-acetyl-5'-me...

α-[(2-carboxy-4-methoxyphenyl)-amino]-γ-butyrolactone Structure

α-[(2-carboxy-4...

~%

1'-acetyl-5'-methoxyspiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-acetyl-5'-me...

2-Amino-5-methoxybenzoic acid Structure

2-Amino-5-metho...

~%

1'-acetyl-5'-methoxyspiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-acetyl-5'-me...

1'-acetyl-4,5-dihydro-5'-methyl-1'H-spiro[furan-3(3H),2'-indoline]-2,3'-dione Structure

1'-acetyl-4,5-d...

~87%

1'-acetyl-5'-methylspiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-acetyl-5'-me...

2-Amino-5-methylbenzoic acid Structure

2-Amino-5-methy...

~%

1'-acetyl-5'-methylspiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-acetyl-5'-me...

α-[(2-carboxy-4-methylphenyl)amino]-γ-butyrolactone Structure

α-[(2-carboxy-4...

~%

1'-acetyl-5'-methylspiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-acetyl-5'-me...

3-Bromdihydrofuran-2(3H)-on Structure

3-Bromdihydrofu...

N-Methylanthranilic acid Structure

N-Methylanthran...

~20%

2-[methyl-(2-oxooxolan-3-yl)amino]benzoic acid Structure

2-[methyl-(2-ox...

1'-acetyl-5'-iodo-4,5-dihydro-2H-spiro[furan-3,2'-indoline]-2,3'-dione Structure

1'-acetyl-5'-io...

~73%

1'-acetyl-5'-iodospiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-acetyl-5'-io...

2-Amino-5-iodobenzoic acid Structure

2-Amino-5-iodob...

~%

1'-acetyl-5'-iodospiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-acetyl-5'-io...

5-iodo-2-((2-oxotetrahydrofuran-3-yl)amino)benzoic acid Structure

5-iodo-2-((2-ox...

~%

1'-acetyl-5'-iodospiro[cyclopropane-1,2'-indole]-3'-one Structure

1'-acetyl-5'-io...

N/A Structure

~90%

Spiro[cyclopropane-1,3'-indolin]-2'-one Structure

Spiro[cycloprop...

Anthranilic acid Structure

Anthranilic acid

~%

Spiro[cyclopropane-1,3'-indolin]-2'-one Structure

Spiro[cycloprop...