Reactivity and mechanism of the antitumor action of triazenes II. Interaction of aromatic diazo-derivatives with a model of phenol-type nucleophilic sites of the cell …

…, NP Bel'skaya, VI Shishkina, VA Chernov…

Index: Nifontov, V. I.; Bel'skaya, N. P.; Shishkina, V. I.; Chernov, V. A.; Ershova, Yu. A.; et al. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 3 p. 162 - 166 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 3 p. 277 - 281

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Abstract

In this work we made a comparative study of the reactivity of a number of aryl diazocompounds (I-IX) and 5-diazoimidazole-4-carboxamide (XI) in the reaction of azocoupling with p-cresol--a close chemical model of the phenol-type nucleophilic sites of cell membranes--for a search for possible differences in the reactivity and mechanism of action of the diazocompounds formed in the decomposition of antitumor 3, 3-dimethyl-l- ...