Synlett

Mg (ClO4) 2 as a powerful catalyst for the acylation of alcohols under solvent-free conditions

…, R Dalpozzo, E Marcantoni, M Massaccesi, S Rinaldi…

Index: Bartoli, Giuseppe; Bosco, Marcella; Dalpozzo, Renato; Marcantoni, Enrico; Massaccesi, Massimo; Rinaldi, Samuele; Sambri, Letizia Synlett, 2003 , # 1 p. 39 - 42

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Citation Number: 78

Abstract

In order to assess the potential of Mg(ClO 4 ) 2 , a series of preliminary experiments were carried out by adding 1 mmol of a primary alkyl alcohol (1-octanol) to 1.05 mmol of Ac 2 O containing decreasing amounts of the Lewis acid at room temperature (Table [1] ). Under these conditions, 1 mol% of Mg(ClO 4 ) 2 is sufficient to quantitatively afford the acetate in a few minutes. Even with 0.1 mol% of the catalyst the reaction goes to completion within a very ...