Novel anthraquinone derivatives with redox-active functional groups capable of producing free radicals by metabolism: are free radicals essential for cytotoxicity?

…, I Ringel, I Ginsburg, A Samuni, J Katzhendler

Index: Barasch, Dinorah; Zipori, Omer; Ringel, Israel; Ginsburg, Isaac; Samuni, Amram; Katzhendler, Jehoshua European Journal of Medicinal Chemistry, 1999 , vol. 34, # 7-8 p. 597 - 615

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Citation Number: 42

Abstract

The mode of action of antitumour anthraquinone derivatives (ie mitoxantrone) is not clearly established yet. It includes, among others, intercalation and binding to DNA, bioreduction and aerobic redox cycling. A series of anthraquinone derivatives, with potentially bioreducible groups sited in the side chain, have been synthesized and biologically evaluated. Their redox and cytotoxic activities were screened. Derivatives which bear a 2-( ...