Comparative Study of the Chemoselectivity and Yields of the Synthesis of N??Alkyl??4??(trihalomethyl)??1H??pyrimidin??2??ones

N Zanatta, D Faoro, L da S Fernandes…

Index: Zanatta, Nilo; Faoro, Debora; Fernandes, Liana Da S.; Brondani, Patricia B.; Flores, Darlene C.; Flores, Alex F. C.; Bonacorso, Helio G.; Martins, Marcos A. P. European Journal of Organic Chemistry, 2008 , # 34 p. 5832 - 5838

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Citation Number: 20

Abstract

Abstract This paper reports a comparative study of the chemoselectivity and yields of the synthesis of N-alkyl-4-(trihalomethyl)-1H-pyrimidin-2-ones carried out by the cyclocondensation of 4-alkoxy-1, 1, 1-trihalo-3-alken-2-ones (enones) with methyl-and allylureas with the N-alkylation of 4-(trihalomethyl)-1H-pyrimidin-2-ones with methyl iodide and allyl bromide. To determine the chemoselectivity of the products obtained, all ...