Increased hydrophobicity and estrogenic activity of simple phenols with silicon and germanium-containing substituents

…, Y Miyajima, H Masuno, H Kagechika

Index: Fujii, Shinya; Miyajima, Yu; Masuno, Hiroyuki; Kagechika, Hiroyuki Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 160 - 166

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Citation Number: 12

Abstract

Here, we report the systematic synthesis and characterization of simple phenols bearing a trialkyl (aryl) silyl or trialkyl (aryl) germyl functional group as a hydrophobic substituent. These silicon and germanium analogues exhibited higher hydrophobicity than the corresponding carbon analogues, with a difference in log P value of approximately 0.6, independent of the alkyl (aryl) species. Trimethylsilylphenol and trimethylgermylphenol ...