Direct Synthesis of Aryl Ketones by Palladium??Catalyzed Desulfinative Addition of Sodium Sulfinates to Nitriles

J Liu, X Zhou, H Rao, F Xiao, CJ Li…

Index: Liu, Jing; Zhou, Xianya; Rao, Honghua; Xiao, Fuhong; Li, Chao-Jun; Deng, Guo-Jun Chemistry - A European Journal, 2011 , vol. 17, # 29 p. 7996 - 7999

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Citation Number: 2

Abstract

Aryl ketones are fundamental intermediates in many types of organic compound, for example, pharmaceuticals, fragrances, and natural products.[1] Classical routes to synthesize aryl ketones mainly rely on the Friedel–Crafts acylation of aromatic compounds in the presence of corrosive AlCl3 [2] and the oxidation of the corresponding secondary alcohols.[3] Transition-metal-catalyzed reactions provide many opportunities for the ...

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