Template-constrained cyclic peptides: design of high-affinity ligands for GPIIb/IIIa

…, W DeGrado, A Dwivedi, A Parthasarathy…

Index: Jackson, Sharon; DeGrado, William; Dwivedi, Anil; Parthasarathy, Anju; Higley, Anne; Krywko, James; Rockwell, Arlene; Markwalder, Jay; Wells, Greg; Wexler, Ruth; Mousa, Shaker; Harlow, Richard Journal of the American Chemical Society, 1994 , vol. 116, # 8 p. 3220 - 3230

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Citation Number: 163

Abstract

Abstract: Although peptides adopt a large ensemble of conformations in aqueous solution, they are generally believed to bind to a receptor in a unique conformation. Thus, there is considerable interest in devising methods to restrict the conformational freedom of peptides. One such approach involves tying the amino and carboxy terminal endsof the peptide onto a semirigid template that will lock the intervening peptide backbone into a single conformer ...