Synthesis of H-bonding probes of α7 nAChR agonist selectivity

J Wang, RL Papke, NA Horenstein

Index: Wang, Jingyi; Papke, Roger L.; Horenstein, Nicole A. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 474 - 476

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Citation Number: 4

Abstract

The α7 subtype of the nicotinic acetylcholine receptor (nAChR) is the target of studies aimed at identifying features that will lead to the development of selective therapeutics. Five arylidine anabaseines, three with pyridine rings and two with the pyrrole rings, were synthesized in 35–65% yield via aldol condensation. The compounds are homologs of benzylidine anabaseine and were chosen for synthesis because they provide either a ...