Tetrahedron

Facile oxidative conversion of hydrazides of carboxylic acids to corresponding acids, esters and amides using copper compounds

J Tsuji, T Nagashima, NT Qui, H Takayanagi

Index: Tsuji, Jiro; Nagashima, Toshiharu; Qui, Nguyen Thi; Takayanagi, Hiroshi Tetrahedron, 1980 , vol. 36, p. 1311 - 1315

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Citation Number: 30

Abstract

Oxidative conversion of hydrazides of carboxylic acids to acids, esters and amides using Cu salts was studied. Acids were obtained in high yields by using a catalytic amount of Cu (OAc) 2 at room temperature by bubbling oxygen. Hydrazides were converted to esters by the treatment with Cu (OR) Cl or Cu (OR) 2 formed in situ from CuCl2 and sodium alkoxide. Amides were obtained in high yields by the oxidation of hydrazides with CuCl2 in the ...