Chemistry - A European Journal 2017-08-09

Ligand- and Solvent-Tuned Chemoselective Carbonylation of Bromoaryl Triflates

Chaoren Shen, Zhihong Wei, Haijun Jiao, Xiao-Feng Wu

Index: 10.1002/chem.201703190

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Abstract

A palladium-catalyzed chemoselective carbonylative transformation of bromoaryl triflates has been established. The selective C−Br versus C−OTf functionalization can be remarkably tuned by the combination of ligand (Xantphos vs. DPPF) and solvent (toluene vs. DMSO). The respective ligand and solvent effects were rationalized by DFT calculations. More information can be found in the Full Paper by H. Jiao and X. F. Wu et al. (DOI: 10.1002/chem.201702015).