Tetrahedron Letters

Solvent-free copper-catalyzed N-arylation of amino alcohols and diamines with aryl halides

…, M Jin, W Chen, C Chen, L Zheng, P Wei, S Han

Index: Yin, Huiqing; Jin, Ming; Chen, Wei; Chen, Chen; Zheng, Likang; Wei, Ping; Han, Shiqing Tetrahedron Letters, 2012 , vol. 53, # 10 p. 1265 - 1270

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Citation Number: 24

Abstract

Transition-metal-catalyzed amination of aryl halides represents an important method and is widely used in the synthesis of many substances including drugs, materials, natural products, agrochemicals, and optical devices. 1 Typically, C–N bonds are formed by Ullmann-type coupling processes. However, the classical coupling reaction generally suffers from several shortcomings including high reaction temperatures, moderate yields, extended reaction times, and poor ...