Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome

SM Lynch, J DeVicente, JC Hermann…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 9 p. 2793 - 2800

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Citation Number: 13

Abstract

... Bioorganic & Medicinal Chemistry Letters. Volume 23, Issue 9, 1 May 2013, Pages 2793–2800. ... Conformational constraint is a well-known medicinal chemistry strategy for preorganization of a flexible ligand into a biologically active conformation. ...