Tetrahedron

Synthesis of all four nucleoside-based β-amino acids as protected precursors for the synthesis of polyamide-DNA with alternating α-amino acid and nucleoside-β- …

S Bagmare, M Varada, A Banerjee, VA Kumar

Index: Bagmare, Seema; Varada, Manojkumar; Banerjee, Anjan; Kumar, Vaijayanti A. Tetrahedron, 2013 , vol. 69, # 3 p. 1210 - 1216

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Citation Number: 4

Abstract

A simple approach is described for the synthesis of all four orthogonally protected nucleoside-β-amino acids from commercially available starting materials. Synthesis of a model tetrameric DNA sequence in 5′–3'direction employing trityl strategy and glycine as α- amino acid alternating with nucleoside-β amino acids is described.