1. Single doses of 3, 3′, 4, 4′-tetrachlorobiphenyl (TCB) were administered intraperitoneally to the male Wistar rat for metabolism studies. 2. Seven sulphur-containing metabolites of TCB were isolated from faeces, in addition to previously reported 4-hydroxy-3, 3′, 4′, 5-tetrachlorobiphenyl and 5-hydroxy-TCB. Major sulphur-containing metabolites were 5-and 6-methylthio-TCBs, and 6-methylsulphonyl-3-methylthio-3′, 4, 4′- ...
