Nature Medicine 2017-11-13

Enhancing the precision of genetic lineage tracing using dual recombinases

Lingjuan He, Yan Li, Yi Li, Wenjuan Pu, Xiuzhen Huang, Xueying Tian, Yue Wang, Hui Zhang, Qiaozhen Liu, Libo Zhang, Huan Zhao, Juan Tang, Hongbin Ji, Dongqing Cai, Zhibo Han, Zhongchao Han, Yu Nie, Shengshou Hu, Qing-Dong Wang, Ruilin Sun, Jian Fei, Fengchao Wang, Ting Chen, Yan Yan, Hefeng Huang, William T Pu, Bin Zhou

Index: 10.1038/nm.4437

Full Text: HTML

Abstract

Enhancing the precision of genetic lineage tracing using dual recombinases Enhancing the precision of genetic lineage tracing using dual recombinases, Published online: 13 November 2017; doi:10.1038/nm.4437NatureArticleSnippet(type=short-summary, markup= Genetic cell-lineage tracing studies in mice are crucial for delineating the contribution of stem and progenitor cells to different cell types, both in disease states and after regenerative therapy. He et al. have developed new genetic lineage-tracing systems that provide more definitive results than the commonly used Cre-based system and show that this new technology can resolve current controversies in the field, as demonstrated by lineage-tracing studies in the heart and liver., isJats=true)