Synthesis and cytotoxic activity of 2-acetylcyclopent-4-ENE-l, 3-diones and their derivatives

…, VL Novikov, NG Prokof'eva, EL Chaikina

Index: Shestak; Novikov; Prokof'eva; Chaikina Pharmaceutical Chemistry Journal, 1999 , vol. 33, # 12 p. 631 - 634

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Citation Number: 5

Abstract

In solution, triketones I represent a mixture of four enolic forms [2]. Two of these forms contain both a carbonyl-conjugated l'-hydroxyethylidene group and the 2-ene-l, 4-dione fragment, which makes them structurally similar to cyclopentane-based antitumor antibiotics such as pentenomycins [3, 4](including sarcomycin [5] used in clinical practice), as well as clavulones, chloro (boromo, iodo) valones, and pimaglandins [6, 7]. As is known, 2-alkyl ( ...