Synthesis and structure-function studies of melanocyte stimulating hormone analogs modified in the 2 and 4 (7) positions: comparison of activities on frog skin …

…, MD Bregman, ME Hadley, CB Heward

Index: Hruby; Sawyer; Yang; Bregman; Hadley; Heward Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1432 - 1437

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Citation Number: 44

Abstract

The synthesis and purification of several analogues of the melanotropins with amino acid substitutions at the tyrosine-2 and methionine-4 (7) positions are reported. The compounds synthesized included [4-norleucine]-a-MSH,[7-norleucine]-P,-MSH,[2-3', 5'-diiodotyrosine]-a- MSH,[2-~-tyrosine]-a-MSH, and [2-phenylalanine, 4-norleucine]-a-MSH, The biological activities of these derivatives were measured and compared on normal melanocytes (frog ...