e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Using intelligent/random library screening to design focused libraries for the optimization of homogeneous catalysts: Ullmann ether formation
…, E Hauptman, R Shapiro, A Casalnuovo
Index: Fagan, Paul J.; Hauptman, Elisabeth; Shapiro, Rafael; Casalnuovo, Albert Journal of the American Chemical Society, 2000 , vol. 122, # 21 p. 5043 - 5051
A 96-member “pyridine” library consisting of both rationally chosen and “random” members was used to screen Ullmann ether forming reactions. The reaction of 2-bromo-4, 6- dimethylaniline and other substrates with a variety of alkoxides was investigated under different conditions with the aid of an automated liquid handler. From the results of the 96- member library screening, a structure activity profile was determined which led to the ...
