Abstract The synthesis and characterization of N 6 (N-methyl-2-pyrrolidine amidine) 2′- deoxyadenosine is described. This amidine is significantly more stable toward acid catalyzed depurination than N-benzoyldeoxyadenosine, is easy to prepare and can be removed rapidly and quantitatively.
![N'-[9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]-N,N-dimethylmethanimidamide Structure](https://image.chemsrc.com/caspic/429/17331-12-3.png)
![(2R,3S,5R)-2-(hydroxymethyl)-5-[6-[(1-methylpyrrolidin-2-ylidene)amino]purin-9-yl]oxolan-3-ol Structure](https://image.chemsrc.com/caspic/431/88010-85-9.png)
