Helvetica chimica acta

Chiral Cooperativity: The Effect of Distant Chiral Centers in Ferrocenylamine Ligands upon Enantioselectivity in the Gold (I)??Catalyzed Aldol Reaction

SD Pastor, A Togni

Index: Pastor, Stephen D.; Togni, Antonio Helvetica Chimica Acta, 1991 , vol. 74, # 5 p. 905 - 933

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Citation Number: 34

Abstract

Abstract Long-range chiral cooperativity in enantiomerically pure ferrocenylamine ligands containing both planar and multiple centers of chirality (multiple stereogenic C-atoms) was demonstrated in the Au I-catalyzed reaction of aldehydes and isocyanoesters. Synthetic methodology was developed for the synthesis of ferrocenylamine ligands with two and three chiral centers of known absolute configuration in the C-side chain in addition to the planar ...