Facile benzannulation of isocoumarins in the efficient synthesis of diversified 1, 3-disubstituted isoquinolines

P Manivel, K Prabakaran, FN Khan, JS Jin

Index: Manivel; Prabakaran; Khan, F. Nawaz; Jin, Jong Sung Research on Chemical Intermediates, 2012 , vol. 38, # 2 p. 347 - 357

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Abstract

Abstract An efficient and facile one-pot synthesis of 1, 3-disubstituted isoquinolines 3 was accomplished from 3-substituted isocoumarins 1 through diketones, formed in situ via the Grignard reaction, in the presence of ammonium acetate, montmorillonite K-10 catalyst, and ethanol solvent. Graphical Abstract R= Phenyl, 4-chlorophenyl, 4-methylphenyl R′= phenyl, methyl, isopropyl, cyclopentyl, cyclohexyl, 3-methoxyphenyl, 2, 4-dichlorphenyl, ...