Abstract A practical synthesis of 5-(chloromethyl) furo [2, 3-b] pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L-754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from commercially available methyl 2-furoate.
![ethyl furo[2,3-b]pyridyne-5-carboxylate Structure](https://image.chemsrc.com/caspic/068/160729-90-8.png)
![Furo[2,3-b]pyridine-5-methanol (9CI) Structure](https://image.chemsrc.com/caspic/297/169815-81-0.png)
![4-chlorofuro[2,3-b]pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester Structure](https://image.chemsrc.com/caspic/422/124031-00-1.png)