A novel, mild, and facile method to prepare 6-methylidene penem derivatives

…, I Yamamura, K Hayashi, T Kumagai…

Index: Hayashi, Kazuhiko; Kumagai, Toshio; Nagao, Yoshimitsu Heterocycles, 2000 , vol. 53, # 2 p. 447 - 452

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Citation Number: 18

Abstract

A novel and mild method was established to synthesize 6-methylidene penem compounds. This method entails a MgBr2/Et3N-promoted aldol-type condensation on 6-bromopenem 12 with an appropriately substituted aldehyde to yield the intermediate acetylated bromohydrin,