Enantioselective Hydrogenation of Allylphthalimides: An Efficient Method for the Synthesis of β??Methyl Chiral Amines

CJ Wang, X Sun, X Zhang

Index: Wang, Chun-Jiang; Sun, Xianfeng; Zhang, Xumu Angewandte Chemie - International Edition, 2005 , vol. 44, # 31 p. 4933 - 4935

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Citation Number: 33

Abstract

Chiral amines bearing a β-methyl group on the chiral center, and their derivatives, are key structural elements in natural products and pharmaceuticals.[1–3] For example, compound A is a key intermediate in the synthesis of the leukotrienes (LTs) receptor antagonist (Zeneca ZD3532, a phase II drug candidate; Scheme 1). This compound is particularly useful for the treatment of asthma.[2] Compound B (NPS 1392) is a potent stereoselective antagonist of ...